The paucity of cases may be due to either underreporting or improvement in the diagnosis and treatment of uncomplicated hypothyroidism. Articulo especial coma mixedematoso resena historica. Myxedema coma is a rare lifethreatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis. Myxedema coma, also known simply as myxedema, is a rare but potentially deadly manifestation of severe hypothyroidism. Cecil medicine, 24th edition edited by lee goldman and andrew i. Fortunately, it is now a rare presentation of hypothyroidism, likely due to earlier diagnosis as a result of the widespread. However, despite the ready availability of sensitive thyrotropin assays, the recognition and treatment of myxedema coma. The term myxedema coma is a misnomer, and myxedema crisis may be an apt term as quite a few patients are obtunded, rather than. A bulging anterior fontanel may indicate increased cranial pressure. Bizarre statements abound, such as in myxedema, because of the reduced cardiac output and vasomotor changes, lengthy syncope seems to be common. Myxedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing of function in multiple organs.
Hypothyroidism is a frequently diagnosed and simply treated disease. Sep 23, 20 most downloaded clinica chimica acta articles the most downloaded articles from clinica chimica acta in the last 90 days. The assumption is made that physiological aberrations in myxedema coma must be identical with those changes seen in induced hypothermia, since hypothermia often accompanies the former. Apr 25, 2018 myxedema coma is a rare lifethreatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis. Mixedema generalizado del adulto con evolucion a coma.
Our partners will collect data and use cookies for ad personalization and measurement. If you continue browsing the site, you agree to the use of cookies on this website. Myxedema and coma severe hypothyroidism endotext ncbi. The leading text in pediatric nursing, wongs nursing care of infants and children takes a unique, easytounderstand developmental approach to describe the care of children at each age and stage of development.
Evaluacion preanestesica del paciente hipertension alergia. Childhood diseases and disorders are organized by age groups and body systems, and described through the nursing process framework. Repigmentation of gray hair after thyroid hormone treatment. Elsevier is a leading publisher of health science books and journals, helping to advance medicine by delivering superior education, reference information and decision support tools to doctors, nurses, health practitioners and students. Citescore values are based on citation counts in a given year e. Acromegalia felina, 708 acromegalia versus hiperadrenocorticismo, 711 nanismo pituitario, 711 predisposicao, 712 sinais clinicos, 712 disturbios da glandula.
Approach to medicine, the patient, and the medical profession. Pdf free download flatform start research documents. As alteraes mentais relacionadas ao hipotireoidismo so apatia, depresso, retardo psicomotor e alteraes da memria. Most patients, however, are not comatose, and the entity rather represents a form of very severe, decompensated hypothyroidism. Coma mixedematoso cuando sospecharlo y como manejarlo.
Myxedema coma is a severe and lifethreatening form of decompensated hypothyroidism with an underlying precipitating factor. Because most atrisk patients, including those with known hypothyroidism, thyroidectomy or previous radioactive iodine therapy, are routinely. Pdf hypothyroidism is a frequently diagnosed and simply treated disease. Most downloaded clinica chimica acta articles elsevier. Sep 15, 2011 myxedema coma is a severe and lifethreatening form of decompensated hypothyroidism with an underlying precipitating factor. Em apresentaes agudas e graves, como no coma mixedematoso, delirium e psicose so mais frequentes. Procalcitonin in patients with severe coronavirus disease 2019 covid19. The high mortality rate of 2550 % makes early diagnosis and treatment imperative 1, 2. Mixedema generalizado del adulto con evolucion a coma mixedematoso. Encyclopedia of endocrine diseases 2nd edition elsevier.
Myxedema coma definition, symptoms, causes, treatment. May 31, 2017 myxedema coma, also known simply as myxedema, is a rare but potentially deadly manifestation of severe hypothyroidism. Some symptoms of myxedema coma include fatigue, lethargy, depression, dry skin, and weight gain. Protocolo diagnostico y terapeutico del coma mixedematoso. Pdf myxedema coma is the most severe and deepest form of hypothyroidism. Tirotoxicosis y coma mixedematoso slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. It serves as a useful and comprehensive source of information spanning the many and varied aspects of the endocrine end metabolic system. It is a medical emergency with a high mortality rate. Alteracion del estado mental, bradicardia, hipotension, hipoxemia, hipoglucemia e hiponatremia. Myxedema coma or myxedema crisis is a lifethreatening complication of hypothyroidism. However, many middle eastern, north african and iberian jews spoke and wrote arabic indeed, had names written in arabic and judeoarabic, or wrote arabic using hebrew characters judeoarabic, with importation of some hebrew words. Scribd is the worlds largest social reading and publishing site. Feb 18, 2016 tirotoxicosis y coma mixedematoso slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
The mortality rates may be as high as 2560% even with best possible treatment 15. O megaclon mixedematoso representa uma condio potencialmente grave, porm tardia na evoluo. If not recognised, however, in time it may develop into the most severe manifestation of hypothyroidism known as myxedema coma. Apr 09, 2015 the classical hebrew words for the book are ha sefer. Mild myxedema coma usually is treated by a general practitioner or internist while moderate to severe myxedema coma is treated and managed by an endocrinologist.
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